The Methylation Profile tests for single nucleotide polymorphisms (SNPs) that may influence and impair the function of key metabolic pathways including methylenetetrahydrofolate reductase (MTHFR), folate and B12 metabolism, transsulfuration and homocysteine.

The methylation cycle is involved in a plethora of important functions in the body from healthy gene expression and immune cell function to energy production and weight management. The methylation cycle is also responsible for the regulation of homocysteine levels, that can influence the pathogenesis of certain chronic diseases.

What do the results mean?

The Methylation Profile can be used to help identify modifiable risk factors for diabetes, depression, cardiovascular disease, reproductive issues, healthy cell production and cognitive dysfunction. Results from the methylation profile may help to determine a predisposition to altered metabolism of folate, B12, B6, SAMe and methionine.

The Methylation Profile helps in identifying important contributing factors to many common chronic diseases. Results of the profile can help to develop therapeutically appropriate lifestyle, nutritional and supplemental treatment protocols to optimise your health.

What biological functions are better understood through this profile?

The Methylation Profile has implications in a wide variety of biological functions, including but not limited to:

Healthy gene expression.

DNA synthesis and repair.

Detoxification.

Hormone metabolism.

Immune cell function.

Energy production.

Cell membrane function.

Neurotransmitter production.

Inflammation.

Metabolism and weight management – mental health and emotional wellbeing.

Symptoms and conditions best suited to this profile

Alcohol and chemical sensitivity.

Anaemia.

Anxiety, behavioural and mood disorders.

Autism.

Birth defects.

Cancer.

Cardiovascular disease (CVD).

Congenital heart disease.

Detoxification impairment.

Family history of heart disease, depression or inflammatory disorders.

General health and longevity – Genetic disorders.

Immune dysfunction.

Lingering fatigue.

Migraines.
Neurodegenerative diseases – Neuropathy.

Nutritional deficiencies.

Preconception care.

Pregnancy.

Psychiatric disorders.

Sleep issues.